Scientists have discovered that tRNAs can determine how long mRNAs exist in a cell, causing some messages to be stabilized ...

High mutational load tumors mitigate effects from protein-damaging mutations by up-regulating complexes that buffer against misfolding stress, revealing therapeutic vulnerabilities and suggesting ...

The collaboration aims to identify a small molecule that targets mutant androgen receptor (AR) mRNA splicing and causes selective destruction of the disease-causing mRNA. By modulating mRNA splicing, ...

科学家发现，转运 RNA (tRNA) 能够决定信使 RNA（mRNA）在细胞中的寿命，导致某些 mRNA 被稳定保存并翻译成更多的蛋白质，而另一些 mRNA 则被降解，从而限制蛋白质的生成量。

Our findings indicate that human DCP1 promotes decapping in vivo and that DCP1a and DCP1b play redundant roles in the general 5′–3′ mRNA decay pathway. We found that EVH1 domain may be crucial for ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction ...

mRNA encoding tail-anchored proteins, with the first transmembrane helix close to ... we further compared our model-derived half-lives with a simple “one minus exponential decay” model that we fit on ...

The authors carried out massively parallel mRNA decay measurements on over 50,000 mRNAs, revealing the interactions controlling mRNA stability in bacteria. Biophysical modeling and machine ...

Investing.com -- Shares of Moderna Inc (BMV:MRNA) (NASDAQ:MRNA) were up roughly 7% at $41, while those of Pfizer Inc (NYSE:PFE)were up nearly 2%. Jefferies analysts said Investor sentiment around ...

After hours: November 22 at 7:59 PM EST ...