For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.

衰老干预技术领域取得的突破，为实现延缓衰老提供了解决方案。据中华医学会老年医学会发布的《延缓衰老药物干预研究中国老年医学专家共识 (2024)》显示，目前有前景的延缓衰老策略包括适度降低营养物感应网络活性、降低雷帕霉素蛋白复合物1 (mTORC1)的活性、去除衰老细胞、利用身体的内源代谢物重新焕发干细胞活力以及优化机体微生物组等。

Notably, the emergence of SMC-derived luminal myofibroblasts—in both mice and patients with KD, Takayasu’s arteritis and Giant Cell arteritis—coincided with activation of the mechanistic target of ...

Long-term, low-dose cannabis treatment has been shown to reverse brain aging and enhance cognitive abilities in mice by ...

Recently, it was shown that MSU crystals can induce mechanistic target of rapamycin (mTOR) signalling in monocytes encountering these crystals in vitro. The mTOR pathway is strongly implicated in ...

uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of mTOR ...

Introduction: Depression is a common psychological disorder, accompanied by a disturbance of the gut microbiota and its metabolites. Recently, microbiota-derived tryptophan metabolism and AMPK/mTOR ...