For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.

However, at pH 6.6, IL-2R signaling was only modestly impacted, and the MAPK/ERK pathway not at all. In contrast, at pH 6.6 we observed that both mTORC1 activation/signaling (as evaluated by ...

These findings reveal that the mTORC1 signaling pathway plays an essential role in the development and function of the striatal inhibitory neurons and suggest the critical involvement of the mTORC1 ...

A new review of the existing evidence shows how dietary interventions like keto, the Mediterranean diet, or intermittent ...

He described the main metabolic pathways involved in the health benefits of the four studied diets, including, most prominently: mammalian target of rapamycin complex 1 (mTORC1) AMP-activated ...

Transcriptomic profiling of osteoblastic osteosarcoma cells demonstrated a higher activation of oxidative phosphorylation, reactive oxygen species, mTORC1, hypoxia signaling pathways, and MYC gene ...

In an era where the pursuit of health and longevity has become the ultimate luxury, a new breed of resorts is emerging, ...

Impact of prophylactic dexamethasone on the efficacy of immune checkpoint inhibitors plus platinum-based chemotherapy in patients with advanced Non-Squamous Non-Small-Cell lung cancer.