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26 天
武汉大学研究团队在基因组同源重组修复调控领域取得新进展
同源重组修复的关键基因发生突变会导致小鼠胚胎致死。在同源重组修复过程中,复制蛋白A(RPA)能够迅速识别末端切除产生的3′端ssDNA并与之结合。随后,重组酶Rad51需要及时替换RPA与ssDNA结合形成Rad51核蛋白纤丝,从而进行同源模板搜索、链入侵及后续修复 ...
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