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An inability to detect the regeneration of acetyl-CoA from succinyl-CoA during autotrophic growth of M. sedula led Fuchs and co-workers to propose a modified form of this pathway in this autotroph.

FBP, fructose 1,6-bisphosphate; ISCD, inter-subunit contact domain. Figure 2. Basic function of PKM2 dimer and tetramer. PKM2, pyruvate kinase M2; FBP, fructose 1,6-bisphosphate; SAICAR, ...