Here, we identify the RNA-binding protein ZCCHC24 as enriched in the mesenchymal-like TNBC population. ZCCHC24 promotes the expression of a set of genes related to tumorigenicity and treatment ...

Researchers successfully tested the safety and preliminary efficacy of stem-cell-derived corneal implants, showing promise ...

Hence, this study identifies a NIC-triggered pathway regulating the stemness and tumorigenicity of ISCs and suggests the use of DBZ as a potential therapeutic strategy for treating intestinal tumors.

(A and B) Image of Ki67-positive cells (Red: Ki67, Blue: DAPI) and their quantification at the crypt base of proximal jejunum (A) or colon (B) of NIC-treated and untreated mice (A:3–4 mice per group, ...

Results Accumulation of monocytic MDSCs (M-MDSCs), but not polymorphonuclear MDSCs, in fibrotic livers significantly correlated with reduced tumour-infiltrating lymphocytes (TILs) and increased ...

Carbonic anhydrases (CAs) are widespread enzymes in bacteria, archaea and eukaryotes, and catalyze a crucially important physiological reaction: the hydration of carbon dioxide to bicarbonate and ...

神经干细胞在中枢神经系统的生长发育中起着至关重要的作用，但随着神经系统疾病的发生，神经细胞的变性死亡是不可避免的。研究表明，移植的神经干细胞可以替代受损的细胞，还可以通过旁分泌作用促进神经组织再生和恢复正常功能。外泌体作为重要的旁分泌介质，不仅在物质 ...

C-reactive protein, interleukin (IL)-6, IL-8, IL-10, monocyte chemoattractant protein-1, soluble tumor necrosis factor receptor I, soluble form suppression of tumorigenicity 2, matrix ...

The predictions for tumorigenicity were assigned a score of false positive (FP), false negative (FN), true positive (TP), or true negative (TN). Regarding the predictions based on any dose of a ...

In humans, the main molecular energy carrier is adenosine triphosphate (ATP). It is critical for cellular functions all over ...