The cloning of green fluorescent protein (GFP), engineering of chimeric fusion proteins, and advances in fluorescence imaging methods have made it possible for researchers to follow the dynamics ...

The endoplasmic reticulum (ER)-localized transmembrane proteins IRE1, PERK and ATF6 detect the load of unfolded protein in the lumen of the organelle, serving as stress receptors. They transduce ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The mevalonate pathway produces essential ...

This work describes a circadian regulation in the expression of HERP, a regulator of endoplasmic reticulum calcium, in primary astrocytic cultures. This work is important because it highlights the ...

Tunicamycin, a substance with a known different mode of action causing protein missfolding activated two modules associated with the inflammatory phase (14 and 39), but none of the modules associated ...

The decrease in cardiac systolic function induced by tunicamycin was also alleviated by rapamycin treatment. Interestingly, in the Sesn2 cKO group, the use of rapamycin to inhibit mTORC1 pathway ...

Department of Physiology, Kochi Medical School, Kochi University, Kochi, Japan Olfactory behavior is highly plastic, and the olfactory tubercle (OT), a component of the olfactory cortex and ventral ...

Sesn2 (Sestrin2) is a stress‐induced protein that provides protective effects during myocardial ischemia and reperfusion (I/R) injury, while endoplasmic reticulum (ER) stress may be a pivotal mediator ...