Claudin-1 (CLDN1) is a protein usually found nestled between epithelial cells — which cover internal and external body surfaces — helping to bind them. “It works like a zipper to keep two ...

Tight junctions are crucial for maintaining cell polarity and facilitating signal transduction. Claudin-9 is responsible for creating charge-specific channels in the paracellular space and plays a ...

Claudin is a protein family that contains at ... which are important for signal transduction and cell polarity. Claudin18.2, a known subtype of Claudin18, is weakly expressed in differentiated ...

as well as autologous CAR-T therapies targeting Claudin 18.2 for advanced pancreatic and gastric cancer. “Cell therapies hold a lot of promise for a wide range of hard-to-treat cancers.

Screening for the study suggests that around 38% of patients with gastric or GEJ adenocarcinomas have tumours that express the claudin 18.2 biomarker in more than 75% of their cells, the threshold ...

Claudin 18.2 is a protein found on the surface of certain cancer cells, including those in the stomach. The presence of this ...

Adding an mRNA vaccine to CAR-T cell therapy could be the key to unlocking ... combination – both targeting the cancer-associated antigen claudin-6 – was shown to be safe and well-tolerated ...