Genetics and other DCCT/EDIC ancillary studies have offered ... These act to cross-link proteins, potentially altering their structure and function. Human collagen has a very long half-life ...

The structure of the modified proteins is analyzed by mass-spectrometry ... Monnier VM, Sell DR, Gao X, Genuth SM, Lachin JM, Bebu I; DCCT/EDIC Research Group. Plasma advanced glycation end products ...