and the integral component of the endoplasmic reticulum membrane. These proteins are involved in protein folding chaperones, unfolded protein binding, and RNA-directed DNA polymerase activity (Figures ...

The endoplasmic reticulum (ER) is responsible for folding secretory and membrane proteins, but disturbed ER proteostasis may lead to protein aggregation and subsequent cellular and clinical ...

An important chaperone protein of the endoplasmic reticulum, called BiP, is chemically modified when the production of unfolded proteins declines, and loses the modification when more unfolded ...