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This was accompanied by an impairment of mitochondrial function with reduced expression of carnitine palmitoyltransferase I and an induction of acyl-coenzyme A oxidase-1 (ACOX1), oxidative stress and ...

Inhibition of Rac1 by EHT1864 showed that Rac1 signalling controlled human aSMC proliferation induced by mitogenic stimuli through the signal transducer and activator of transcription 3 (STAT3) ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

Campus Chemical Instrument Center, Mass Spectrometry & Proteomics Facility, The Ohio State University, Columbus, USA ...

Co-opted pathways required by oncogenic KRAS in order to sustain lung tumorigenesis Cytokine signaling and its associated STAT3 and NF-κB activation are required for KRAS-induced tumorigenesis.

Our findings indicate that PFN1 actively promotes vascular smooth muscle cell phenotype switching and neointimal hyperplasia by orchestrating the activation of the p-ANXA2 (phospho-annexin A2)/STAT3 ...