Our findings indicate that PFN1 actively promotes vascular smooth muscle cell phenotype switching and neointimal hyperplasia by orchestrating the activation of the p-ANXA2 (phospho-annexin A2)/STAT3 ...

Increases RANKL expression in vitro. S1P binding to its receptor leads to the activation of ERK and p38 to upregulate COX2 level, leading to increased PGE2 production in the osteoblast. Suppresses ...

Here, we describe how the extracellular signal-regulated kinase (ERK) pathway in osteoblasts controls bone formation by suppressing the mechanistic target of rapamycin (mTOR) pathway. We also show ...