Inflammation leads to draining lymph node lymphangiogenesis through both VEGF-A/VEGFR2- and VEGF-C/VEGFR-3- mediated mechanisms. Lymphatic drainage is directly associated with the degree of lymph ...
Interestingly, activation of EphB4 forward signaling in cultured lymphatic endothelial cells could also trigger VEGFR-3 internalization, indicating possible bidirectional ephrin-B2–EphB4 ...
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