In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...

TMEM106b’s rap sheet is growing. Some of its genetic variants are linked to both Alzheimer’s disease and frontotemporal dementia, and fibrils of this lysosomal protein accumulate in several ...

The autophagic process has been identified as a degradative pathway: cargo, including entire organelles, is sequestered into double-membrane vesicles, known as autophagosomes, and addressed to ...

Hobbling lysosomal function with a suite of inhibitors ramped up this aggregation ... These ARCs were likely microglia, and they contained amyloid filaments within intracellular vesicles. At the time, ...

The selective turnover of mitochondria via autophagy, known as mitophagy, is a major quality control mechanism safeguarding eukaryotic cells, including highly specialized neurons in the mammalian ...

A study led by WEHI and La Trobe University has found a potential new diagnostic marker that could be used to better detect the level of tissue damage in our bodies. Extracellular vesicles (EVs ...

Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University; Beijing 100191, China ...

Exocytosis is the process by which cytoplasmic secretory vesicles fuse with the cellular membrane, releasing contents to the extracellular space. The extrusion of large extracellular vesicles is ...

Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic pH is associated with aging and neurodegenerative diseases. However, the mechanisms elicited by ...