The degree of complexity and crossover within MAPK signaling, and also shifts in pathways such as nuclear factor κB signaling, could also explain the modest effect of p38 inhibitors. The p38α ...

Upon binding, these receptors initiate pro-inflammatory signaling pathways such as the NF-κB and mitogen-activated protein ...

Liver diseases, both acute and chronic, continue to pose significant clinical challenges due to high morbidity and mortality ...

These pathways include nuclear factor- B, p38 mitogen-activated protein kinase, NH 2-terminal Jun kinases/stress-activated protein kinases, hexosamines, and others. In addition, there is evidence ...

Their findings, which were published in Science Advances, also offer new insights into 2'3'-cGAMP's role in cell migration and how the newly identified 2'3'-cGAMP/Rab18/FosB signaling pathway ...

Targeted therapy revolutionized cancer treatment, with gene fusions leading the way when the FDA approved imatinib in 2001 to ...

The company’s novel MAPK-targeted asset, IK-595, is progressing well in its Phase 1 dose escalation ... It is focused on developing novel cancer therapies targeting key signaling pathways that drive ...

This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...

Filled with the top stories to start your day, and emergency news alerts.

Tune into “The Daily Signal Podcast”—your go-to source for original reporting, engaging interviews, and unique coverage of the day’s top stories. Whether you’re commuting, working out ...