Pertinent clinical and hematologic data of the patients are presented in Table 1.Ten of the 12 patients were less than eight years of age. A number had a history of serious bacterial infections ...

这些结果表明，NPM1促进人类肿瘤进展。 为了阐明NPM1对肿瘤进展和抗肿瘤免疫反应的影响，研究人员利用CRISPR-Cas9系统敲除了三种小鼠肿瘤细胞系（结肠癌MC38、黑色素瘤B16F10和肺癌LLC）中的Npm1基因。通过免疫印迹确认了敲除效率。然后将野生型或Npm1缺陷的肿瘤 ...