1 The First Affiliated Hospital (The First School of Clinical Medicine), Guangdong Pharmaceutical University, Guangzhou, China 2 Guangdong Metabolic Diseases Research Center of Integrated Chinese and ...

抑癌基因TP53（编码p53蛋白）通常发挥肿瘤监查的作用。TP53基因突变后转变为癌基因，是多种肿瘤发生发展的驱动因素之一。 中国科学技术大学生命科学与医学部免疫调节与免疫治疗重点实验室教授魏海明课题组发现，p53可以直接调控免疫细胞的发育、分化与 ...

The tumor suppressor p53 is a transcription factor involved in a variety of crucial cellular functions, including cell cycle arrest, DNA repair and apoptosis. Still, a growing number of studies ...

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近日，天津医科大学总医院谢松波教授、钟殿胜教授联合团队在Science Bulletin发表了题为“An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H ...

p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with ...

Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer cases annually. Here we present a thermodynamic model that quantifies and links the major pathways by which ...