The medical cause of Eddie's death was perinatal hypoxia - a lack of oxygen - around the time of birth. The pathologist said it was not possible to state exactly when it occurred. Evidence was ...

A higher caffeine dosing regimen demonstrated significant toxicity. Perinatal caffeine administration is well tolerated, attenuates systemic and brain inflammation, and contributes to improvements in ...

Neonatal hypoxic-ischemic encephalopathy disproportionately affects low- and middle-income ... Here, we studied the pharmacokinetics, safety, and efficacy of perinatal caffeine administration in ...

College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States Purdue Center for Cancer Research, 201 S. University Street, West Lafayette, Indiana 47907, ...

Hypoxia has been a topical issue in biological research, both in aquatic and terrestrial animals. A sufficient oxygen concentration is essential for electron transport within the mitochondria of ...

Here, we report that the ubiquitination-mediated degradation of DBC1 is regulated by the E3 ubiquitin ligase SIAH2 and deubiquitinase OTUD5 under hypoxic stress. Mechanistically, hypoxia promoted DBC1 ...

Here, we demonstrate that mitophagy, which selectively removes damaged or unwanted mitochondria, regulated mitochondrial quality and quantity in vivo. Hypoxia induced extensive mitochondrial ...

The study was limited to infants with evidence of basal ganglia and thalamic (BGT) injury on MRI, a hallmark of acute perinatal hypoxia-ischemia. Severe BGT injury was highly predictive of severe ...