Although the role of innate immune sensing pathways is well-studied in the pathogenesis of malignancies, whether they ...

Proto-oncogenes regulate cell growth; mutations convert them to oncogenes, leading to cancer by disrupting normal cell ...

Given the prevalence of Danon disease across regions, the Company plans to pursue regulatory filings concomitantly in the U.S. and ex-U.S. “From a clinical perspective, the important thing is that we ...

Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.

As society ages, the number of patients suffering from heart failure grows significantly. Fibrosis, or excessive growth of fibrotic tissue in the heart, has been linked to the advancement of heart ...

Unlike their well-known, folded counterparts, intrinsically disordered proteins lack a single, stable three-dimensional structure. Instead, like Proteus, they take on many different conformations. 1 ...

CaMKII activates the HRI/eIF2α signaling pathway and inhibits the proteotoxicity induced by proteasome inhibition through ...

Therefore, new therapeutic strategies need to be identified. Objective We characterised the enzyme protein arginine-methyltransferase 5 (PRMT5) as a novel therapeutic target in CCA. Design We ...

Kim, J. and Sadiora, K. (2024) Systematic Analysis of Post-Translational Modifications for Increased Longevity of ...

Copper is an essential enzyme cofactor in bacteria, but excess copper is highly toxic. Bacteria can cope with copper stress by increasing copper resistance and initiating chemorepellent response.

The phylogenetic trees were estimated on the basis of complete AA sequences of L protein (Panel B), GPC (Panel C), and N (Panel D) from WELV strains, as well as other recognized species within the ...

GCK, germinal center kinase. Created with BioRender.com ... This may be related to the conservative structure of the WFDC domain in WFDC14 and WFDC4’s C-terminal WFDC domain. But the specific ...