Researchers at McMaster University, Canada, have identified a critical biological mechanism involving the protein MANF ...

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In spite of intensive research, glioblastoma remains one of the most lethal types of brain cancer. Temozolomide (TMZ) is used ...

Deep Mutational Scanning (DMS) is an emerging method to systematically test the functional consequences of thousands of sequence changes to a protein target in a single experiment. Because of its ...

The second-strand cDNA synthesis reaction was then performed immediately ... Then, a window of 50 nt was slid along the genome with a 1 nt step. Windows with >75% of the bases below both the global ...

At these high concentrations, TMZ generates another methylated base, 3-methyl adenine (3-meA), which blocks the DNA synthesis ...