In particular, the ratio of ATP production to oxygen consumption (P/O) is considered integral and constant in all discussions of oxidative phosphorylation. This view is maintained despite the fact ...

Its synthesis, which occurs in the mitochondria, through oxidative phosphorylation (OXPHOS) is a complex, multi-step process. When one or more of the elements of this process malfunction ...

In mammals, pyruvate is the primary substrate for lactate production. It plays a critical role in metabolism by linking glycolysis, where it is produced, with the mitochondrial oxidative ...

Defects in the oxidative phosphorylation (OXPHOS) system — the final biochemical pathway in the production of ATP — result in devastating, mainly multisystem diseases. The OXPHOS system is ...

Despite an increase in glycolysis, however, here we show that non-transformed mouse fibroblasts also increase oxidative phosphorylation (OXPHOS) by nearly two-fold and mitochondrial coupling ...

Respiration is vital to all living things because it is the process by which ... Research on mitochondria in the previous decades has been focused on their role in oxidative phosphorylation and ...