该研究揭示，ME2缺失可阻断CD8+T细胞的三羧酸（TCA）循环，导致中间代谢产物富马酸（fumarate）在细胞内堆积。 从治疗干预的角度来说，要想帮CD8 + T ...

Mice injected in the thymus with procainamide-hydroxylamine, a metabolite of procainamide, develop autoimmune features resembling drug-induced lupus. Here, we show that when thymocytes undergo ...

The data analysis is rigorous and the experiments performed are appropriate. The findings of the manuscript will expand upon previous findings of a role for histone deacetylase 3 in thymocyte ...

The hematopoietic stem cells (HSC) reach the thymus from the bone marrow where they become early thymic progenitors (ETP). At this stage several differentiation steps take place starting with the ...

Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells. In this immunofluorescence image ... In the first place, naïve T-lymphocytes are those cells ...

At present there is no broad consensus on whether the apparent 'preoccupation' of the TCR repertoire with MHC molecules is due to the coligation of CD4 or CD8 coreceptors and the TCR by MHC ...

This phenomenon is known as immunodominance. As T cells mature in the thymus—a specialized organ located in the chest—they undergo both positive and negative selection. To survive positive selection, ...

As FOXN1 is selectively expressed in the thymus and skin, skin epithelial cells may have a role in productive T cell ontogeny, as previously shown in in vitro models.16 Our results show that FOXN1 is ...

Comparisons of control and exposed rats using flow cytometry revealed no changes in the numbers of CD4/CD8 T cells, activated T cells or regulatory T cells among ... the immunological Th1/Th2 paradigm ...