The anticonvulsant topiramate causes dose-dependent weight loss in humans and in animal models of diabetes. Toplak and colleagues, therefore, investigated the efficacy and safety of topiramate as ...

It is also approved to prevent migraine headaches. While Topamax is not approved by the Food and Drug Administration (FDA) as a weight loss drug, it can be used off-label for this purpose.

In women with polycystic ovary syndrome (PCOS) and with obesity or overweight, the combination of topiramate and metformin along with a low-calorie diet can result in effective weight loss and ...