中国科学院深圳先进技术研究院合成生物学研究所胡政、中山大学贺雄雷和何真团队在Nature在线发表论文，首次揭示了肿瘤从多克隆向单克隆转变的早期演化新模式，并解析了肿瘤多克隆起源的细胞间通讯与互作机制。这一发现不仅为肿瘤的早期发生机制提供了新的科学视角，同时也为癌症的精准早期筛查和干预提出了新的思路 ...

Field cancerization is defined as the preconditioning of an area of epithelium to tumor growth, either as the result of a clonal proliferation of mutant cells through the epithelium without ...

This realization led Braakhuis and colleagues to define field cancerization as "the growth a mutant clone to produce a field of cells predisposed to subsequent tumor growth". [10] Here ...