It is a survival and proliferation factor for a variety of tumor types. EGFR signals through the RAS/RAF/MEK/ERK pathway. Upon activation by extracellular ligands, EGFR dimerizes and ...
relapsing after EGFR tyrosine kinase inhibitor (TKI) failed to demonstrate both progression-free survival and overall survival superiority (primary end points) for combination ...
Further tests confirmed the result. The signalling cascade downstream of EGFR includes proteins such as RAS, RAF, MEK and ERK. Activation of EGFR by epidermal growth factor (EGF) leads to ...
公开资料显示，恩考芬尼目前已经获美国FDA获批多项适应症，包括于2018年获批与比美替尼（binimetinib，Mektovi）组合疗法治疗带有BRAF ...
RAS家族中的NRAS、HRAS和KRAS突变是与癌症相关的常见基因突变。其中，KRAS是最常见的癌基因。约80%的胰腺癌患者、40%的结直肠癌患者、30%的肺癌患者存在KRAS基因突变。
Then, IL-2 signaling is transduced through three distinct pathways: JAK-STAT, MAPK/ERK and PI3K/Akt/mTOR. Recent studies have identified that the IL-2/IL-2R signaling pathway is an essential ...
Pharmacogenomics. 2014;15(11):1507-1518. MEK/CDK4 PD-0325901 (MEKi) + palbociclib (CDK4i) NCT02022982 MEK/CDK4 Trametinib (MEKi) + palbociclib (CDK4i) NCT02065063 ...
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