Major Finding: Alveolar macrophages (AM) induce dormancy in early disseminated cancer cells (DCC) in the lung. Concept: TGF-β2-TGF-βRIII signaling mediates DCC dormancy and is subverted during ...

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction of effective CD8 + T cell immune responses. Here, we show that this ...