在一项新的研究中，来自德克萨斯大学西南医学中心的研究人员发现tRNA 可以决定 ...

撰文丨王聪编辑丨王多鱼排版丨水成文众所周知，根据中心法则，DNA转录为mRNA，mRNA再翻译为蛋白质，mRNA的降解速率是每个基因产生的蛋白质的数量的主要决定因素，而这又会影响细胞功能。例如，对于mRNA疫苗，mRNA存在更长时间会产生更多蛋白质， ...

Within a cell, DNA carries the genetic code for building proteins. To build proteins, the cell makes a copy of DNA, called ...

High mutational load tumors mitigate effects from protein-damaging mutations by up-regulating complexes that buffer against misfolding stress, revealing therapeutic vulnerabilities and suggesting ...

This study shows that mRNA decay in durum wheat is affected by 3’ UTR structures and domestication-selected single-nucleotide variations, highlighting the importance of non-coding regions in ...

The collaboration aims to identify a small molecule that targets mutant androgen receptor (AR) mRNA splicing and causes selective destruction of the disease-causing mRNA. By modulating mRNA splicing, ...

The first patients have been dosed in a phase 3 trial of an mRNA-based seasonal influenza vaccine developed by Pfizer and BioNTech, which may offer quicker production and greater efficacy than ...

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