protein content, proliferation), 2) the limited data on the requirement of DYRK1A for TSC complex stability and function, and 3) the limited perturbations on the mTORC1 pathway upon DYRK1A ...

Furthermore, the study does not provide a clear mechanistic insight how the claimed CaMKKbeta/CaMKIV-mTORC1 signaling pathway upregulated both GLP-1 production and secretion. This reviewer also has ...

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SPN-820 is a first-in-class, oral small molecule drug designed to enhance synaptic function in the brain by activating the mechanistic target of the rapamycin complex 1 (mTORC1) pathway. This ...

SPN-820 is a first-in-class, oral small molecule drug designed to enhance synaptic function in the brain by activating the ...

Due to its role in the phosphatidylinositol 3-kinase (PI3K) signaling pathway, mTOR is a rational target for inhibition in combination with other agents, including traditional chemotherapy and ...

Skeletal muscle is a vital organ for maintaining health. In this article, we explore how protein feeding and exercise ...

Saul persecuting Christians; Simon, the sorcerer; Philip and the Ethiopian. We make a serious mistake when we say that all our misfortunes and sufferings are caused by sin or Satan. We need to ...