Purespring’s gene therapy, PS-002, uses a viral vector to target kidney cells—known as podocytes—to treat IgA nephropathy, a ...

IgA nephropathy is an autoimmune kidney disease, and complement, a component of the innate immune system, plays a role in the condition's pathogenesis.

A specialized low-salt fasting-mimicking diet revives kidney function in preclinical animal models and patients with chronic ...

In patients with chronic kidney disease, the loss of podocytes—part of the kidney's glomerular filtration barrier—causes irreversible disease progression. So far, physicians and researchers have found ...

IgA nephropathy is an autoimmune kidney disease, and complement, a component of the innate immune system, plays a role in the ...

Cells expressing PAX8 (nucleus, red) considered podocyte precursors, line the outer Bowman’s capsule. Activated during the low salt-fasting mimicking diet (LS-FMD), the cells migrate and ...

A study reveals that a low-salt fasting-mimicking diet slows kidney disease progression in animal models and shows protective ...

IgA nephropathy is an autoimmune kidney disease, and complement, a component of the innate immune system, plays a role in the ...

The glomerular filtration barrier, from the blood to the urinary space, consists of endothelial cells, a basement membrane and specialized epithelial cells called podocytes. Endothelial cells have ...

Cross-sectional images of IgA nephropathy murine kidneys. Purespring gene therapy significantly improves kidney morphology and reduces the areas of scarring and fibrosis stained in blue. Results from ...

Data were also presented supporting a growing body of evidence that LUPKYNIS through unique mechanism of action, favorably ...

目前，我们对肾病的发生发展，特别是细胞和分子层面的认识并不明确。因此，许多肾病患者依然会发展为终末期肾脏病（ESRD），其中我们对糖尿病肾病（DKD）的认识也不是特别明确。特别是为什么有些糖尿病患者终身不发生DKD，而有些在确诊糖尿病时，就已经出现了 ...