We generated knock-in mice expressing a PERK mutant, which is not phosphorylated by Mst1, (PERK-KI). Although PERK was activated by tunicamycin, an ER stress inducer, it was not activated by ...

Chemistry is a core science subject that touches almost every aspect of our daily lives and will become increasingly important in our future knowledge-based society. Chemists develop life-saving drugs ...

Newly made proteins are unstructured chains of amino acids that must fold into particular shapes to work effectively. Proteins that are destined to be exported from the cell undergo folding in a ...