Mechanisms of Ethanol-Induced Cerebellar Ataxia: …
网页2021年8月18日 · Synaptic dysfunction in the cerebellar cortex is at the hallmark of ataxia after acute alcohol intoxication. Two synaptic locations are particularly vulnerable to the acute effects of alcohol: the synapses on the granule cells (GCs) that gate the cerebellar cortex and those on the Purkinje cells (PCs), which represent the cerebellar cortical ...
Alcohol-related cerebellar degeneration: not all down to toxicity?
网页2016年10月3日 · Alcohol-related cerebellar degeneration is one of the commonest causes of acquired cerebellar ataxia. The pathophysiology remains unclear but proposed mechanisms include excitotoxicity, dietary factors, oxidative stress, compromised energy production and cell death [1].
Ataxia - Symptoms and causes - Mayo Clinic
网页2024年1月30日 · Ataxia usually results from damage to the part of the brain called the cerebellum or its connections. The cerebellum controls muscle coordination. Many conditions can cause ataxia, including genetic conditions, stroke, tumors, multiple sclerosis, degenerative diseases and alcohol misuse.
Mechanisms of Ethanol-Induced Cerebellar Ataxia: …
网页2021年8月18日 · Alcohol-dependent patients develop gait ataxia and lower limb postural tremor. Prenatal exposure to ethanol causes fetal alcohol spectrum disorder (FASD), characterized by permanent congenital disabilities in both motor and cognitive domains, including deficits in general intelligence, attention, …
Mechanisms of Ethanol-Induced Cerebellar Ataxia: Underpinnings …
网页2021年8月18日 · We highlight the spectrum of cerebellar damage induced by ethanol, emphasizing physiological-based clinical profiles and biological mechanisms leading to cell death and disorganized development. Keywords: alcohol; cerebellar ataxias; cerebellum; ethanol; fetal alcohol spectrum disorder.
Effects of ethanol on the cerebellum: advances and prospects
网页Excessive alcohol exposure results in cerebellar ataxia and alterations in hand movements, speed when striking a target, impaired postural stability and balance, and slower attenuated foot taping. In addition, the developing cerebellum is particularly vulnerable to the toxic effects of alcohol.
Ethanol-Induced Cerebellar Ataxia: Cellular and Molecular Mechanisms
网页First, ethanol-induced blockade of cerebellar adenosine uptake in rodent models points to a role for adenosinergic A1 modulation of EICA. Second, the consistent observation that intracerebellar administration of nicotine in mice leads to antagonism of EICA provides evidence for a critical role of cerebellar nitric oxide (NO) in EICA reversal.
Ethanol-Induced Cerebellar Ataxia: Cellular and Molecular Mechanisms
网页2015年1月13日 · Clinically, ethanol-induced cerebellar ataxia (EICA) is an important consequence of alcohol consumption and represents an excellent measure of ethanol intoxication. EICA has been used to study the differences in initial sensitivity and acute tolerance to ethanol in several inbred strains of mice suggesting that …
Persistence of cerebellar ataxia during chronic ethanol …
网页We recently demonstrated that acute ethanol-induced ataxia is associated with increased cerebellar Fmr1 gene expression via histone modifications in rats, but it is unknown whether similar behavioral and molecular changes occur following chronic ethanol exposure.
Alcohol and the Cerebellum - PMC - National Center for …
网页These results provide compelling evidence that alcohol-related ataxia is attributable specifically to cerebellar dysfunction. Genetics also may play a role in alcohol-related motor deficits. Using PET, Volkow and colleagues (1995) examined the link between genetic predisposition to alcoholism and reduced sensitivity to alcohol in the brain.