Identification of CircRNA signature associated with tumor immune ...
网页2023年5月3日 · Overall, our study characterizes circRNA profiles and regulatory networks in ICB-treated patients, and highlights the clinical utility of circRNAs as predictive biomarkers of immunotherapy.
Circular RNA hsa_circ_0006401 promotes proliferation and
网页2021年5月4日 · Dysregulation of circular RNA (circRNA) expression is involved in the progression of cancer. Here, we aimed to study the potential function of hsa_circ_0006401 in colorectal cancer (CRC).
CircRNA identification and feature interpretability analysis
网页2024年2月27日 · We developed a novel framework, CircDC, for classifying circRNAs from other lncRNAs. CircDC uses four different feature encoding schemes and adopts a multilayer convolutional neural network and bidirectional long short-term memory network to learn high-order feature representation and make circRNA predictions.
CircNUP54 promotes hepatocellular carcinoma progression via ...
网页2024年3月5日 · Aberrant circRNA expression plays a regulatory role in intracellular signal transduction, which contributes to the tumorigenesis of many cancers , including breast cancer , non-small cell lung ...
New insight into circRNAs: characterization, strategies, and …
网页2023年10月12日 · In this review, we systematically discuss the characterization of circRNAs, databases, challenges for circRNA discovery, new insight into strategies used in circRNA studies and biomedical applications.
TCCIA: a comprehensive resource for exploring CircRNA in cancer ...
网页This visualization revealed discernible circRNA clustering patterns specific to various cancer types, highlighting the nuanced circRNA heterogeneity within human cancers and emphasizing the need for independent circRNA analysis considerations.
Circular RNAs: Emerging roles and new insights in human cancers
网页2023年9月1日 · Mechanisms underlying circRNA function intracellularly. (a) CircRNA can serve as miRNA sponge to reduce the effectiveness of microRNAs. (b) CircRNA can perform as a protein scaffold to prevent protein binding with its targets. (c) CircRNA can regulate transcription and splicing. (d) CircRNA can act as a …
Role of a novel circRNA-CGNL1 in regulating pancreatic cancer ...
网页2024年1月31日 · Here, we discovered a novel circRNA, circCGNL1, that was expressed at low levels in PC tissues and cells. Therefore, we suspected that circCGNL1 acts as a tumor suppressor in PC. We performed gain and loss-of-function assays to determine its biological functions in vitro and in vivo.
The Latest Overview of circRNA in the Progression, Diagnosis, …
网页2021年2月17日 · CircRNA is highly tissue-specific and more stable than linear mRNA, making it a promising prognostic marker for HCC. Circ_0005394 is upregulated in HCC, and overexpression of circ_0005394 is linked with larger tumor size, more advanced TNM stages, and poorer survival outcome for HCC patients .
The emerging landscape of circular RNAs in immunity: breakthroughs …
网页2020年7月10日 · CircRNA in the immune system exhibit several functions: a. regulating the differentiation and development of immune cells, as circRNA can interact with critical factors during immune cell differentiation to differentiate targeted cells; b. regulating the activation state of immune cells and maintaining the homeostasis of cells by regulating ...
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