Interleukin 12 - Wikipedia
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, [1] macrophages, neutrophils, helper T cells and human B- lymphoblastoid cells (NC-37) in …
Interleukin-12 and the regulation of innate resistance and …
2003年2月1日 · Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that regulates T-cell and natural killer-cell responses, induces the production of interferon-γ (IFN-γ), favours …
Interleukin-12: an update on its immunological activities, …
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of the p35 and p40 subunits. It is produced by antigen-presenting cells and plays a critical role in host defense against …
Interleukin 12 (IL-12) Family Cytokines: Role in Immune Pathogenesis ...
Interleukin 12 (IL-12) family is comprised of 4 members, IL-12, IL-23, IL-27 and IL-35. IL-12, IL-23 and IL-27 are secreted by activated antigen presenting cells (APC) during antigen presentation …
IL-12 family cytokines: immunological playmakers - Nature
2012年7月19日 · Among the vast array of bioactive cytokines, the interleukin 12 (IL-12) family is unique. This is the only family of heterodimeric cytokines, which endows them with several …
The Immunobiology of the Interleukin-12 Family: Room for …
The IL-12 family of cytokines influences the outcome of cancer, infection, and inflammatory diseases. Stumhofer, Hunter, and Tait review the combinatorial biology inherent to this family …
Interleukin 12 - an overview | ScienceDirect Topics
Interleukin 12 (IL-12), a cytokine that stimulates T-helper anti-tumor immune responses, could prove beneficial as a therapy in treating cancer. However, the systemic administration of IL-12 …
Interleukin-12: Functional activities and implications for disease
Interleukin-12 (IL-12) was the first member of the IL-12 family of cytokines to be identified and has therefore become its eponym. It is a heterodimeric protein of two subunits (p35, p40) secreted …
Interleukin-12: Biological Properties and Clinical Application
2007年8月15日 · Interleukin-12 (IL-12) is a heterodimeric protein, first recovered from EBV-transformed B cell lines. It is a multifunctional cytokine, the properties of which bridge innate …
Interleukin-12: A Proinflammatory Cytokine with …
Interleukin-12 (IL-12) is a heterodimeric cytokine produced mostly by phagocytic cells in response to bacteria, bacterial products, and intracellular parasites, and to some degree by B …