Influence of picolinic acid on seizure susceptibility in mice
网页Picolinic acid (PIC) is an endogenous metabolite of the kynurenine pathway and a chelating agent added to dietary supplements. Both inhibitory and excitatory properties of PIC were reported. The aim of this study was to determine the influence of exogenously applied PIC upon the electroconvulsive threshold and the activity of chemical ...
(PDF) Pilocarpine - ResearchGate
网页1983年12月31日 — The content of pilocarpine and its inactive degradation products, pilocarpic acid, can be determined by a polarimetric method. The solution is made alkaline with aqueous ammonia and extracted...
Plateau iris: An important anatomical configuration not to miss
网页Miotics such as pilocarpine stretches the iris and opens the angle. Such treatment can be used in temporary control, given its effects on decreasing vision in dim light, and others like myopic shift, uveitis and risk of retinal detachement.
网页眼用Pilocarpine曾造成視力模糊而減低視力的 敏銳度(尤其在夜晚及有眼球中央晶體改變的患者)及造成深度感測受損。當夜晚開 車或在光線不足下從事危險活動時應特別注意。 肺部疾病：Pilocarpine曾報導會增加呼吸道的阻力、支氣管平滑肌的緊張度和支 氣管分泌。
Plateau Iris - an overview | ScienceDirect Topics
网页Plateau iris configuration refers to an iris with a flat central surface and angulated sharp drop-off of the peripheral portion next to the angle wall. 8 Plateau iris syndrome (PIS) is defined as the development of angle closure in an eye with PIC despite the presence of a patent laser iridotomy.
Sonic hedgehog is a regulator of extracellular glutamate levels and ...
网页2016年4月4日 — Inhibiting Shh signaling greatly reduces epileptiform activities in both cell cultures and hippocampal slices. Moreover, pharmacological or genetic inhibition of Shh signaling markedly suppresses epileptic phenotypes in kindling or pilocarpine models.
Mentha piperita Oil Exerts an Antiepileptic Effect in Pilocarpine …
网页2022年9月22日 — Pilocarpine (P) is a muscarinic agonist that is widely used in many laboratories to induce the status epilepticus (SE) model, which is very similar to human diseases . SE is one of the most frequent medical crises affecting epilepsy cases and is clinically characterized as a seizure lasting more than …
Evaluation of possible antioxidant and anticonvulsant effects of …
网页In the EAF 10+P400 group, lipid peroxidation and nitrite levels significantly decreased and SOD and catalase activities significantly increased after pilocarpine-induced seizures. Additionally, effects of the EAF were evaluated in PTZ and PIC models.
网页2016年4月4日 — picrotoxin (Pic) or Mg2+-free (0Mg), conditions known to induce epileptiform activities in slices or cells [22–24], were markedly enhanced within 1 h in hippocampal slices (Fig 1H) or 15 min in hippocampal neurons (Fig 1I). Thus, epileptic neuronal activity rapidly increases Shh release. Consistently, up-regulation of Gli1
Influence of picolinic acid on seizure susceptibility in mice
网页2017年2月1日 — The principal findings of this study are: firstly, PIC administered icv, but not sc, dose dependently induces seizures; secondly, PIC administered sc dose-dependently decreases the electroconvulsive threshold; and finally, PIC enhanced the convulsant activity of PILO, but not of the other convulsants studied.
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