Tumor Structure and Tumor Stroma Generation - Holland-Frei Cancer …
Solid tumors have a distinct structure that mimics that of normal tissues and comprises two distinct but interdependent compartments: the parenchyma (neoplastic cells) and the stroma …
Mesenchymal stromal cells as cancer promoters | Oncogene
2024年10月16日 · Mesenchymal stromal cells (MSCs) are important cellular constituents of tumor stroma that play an active role in tumor development. Complex interactions between...
Targeting the tumour stroma to improve cancer therapy
2018年4月12日 · Most anticancer therapies target cancer cells specifically, but the tumour stroma can promote the resistance of cancer cells to such therapies, eventually resulting in fatal …
Rebuilding the microenvironment of primary tumors in humans: a …
2024年3月5日 · In this review, we summarize the heterogeneity of tumor-associated stromal cells and general deconstruction approaches used to isolate patient-specific stromal cells from …
CD8+ T cells in tumor parenchyma and stroma by image …
2019年5月26日 · Digitized slides were used to train a convolutional neural network to quantify the number of CD8+ T cells in stroma, tumor parenchyma, parenchyma-stromal interface, and …
Targeting the tumor stroma for cancer therapy - Molecular Cancer
2022年11月2日 · As an essential element of the TME, the tumor stroma affects tumor biology and contributes to cancer initiation, progression, metastasis, and therapeutic resistance [6]. The …
Radiogenomic analysis of cellular tumor-stroma heterogeneity as …
2023年11月25日 · To comprehensively assess tumor-stroma phenotypes, we conducted an evaluation of radiogenomic signatures derived from both the tumor and surrounding …
Stroma Cells in Tumor Microenvironment and Breast Cancer
However, emerging evidence indicates that tumors are composed of tumor parenchyma and stroma two discrete but interactive parts that crosstalk to promote tumor growth. Recently, …
Tumor Microenvironment: Aspects of Stromal-Parenchymal
2022年11月2日 · Solid tumors are composed of malignant parenchymal cells embedded in nonneoplastic stroma. A large body of evidence emphasizes that the actual biological behavior …
Direct molecular dissection of tumor parenchyma from tumor stroma …
2018年5月29日 · Here, we report an antibody-free targeted cross-species glycoproteomic (TCSG) approach that enables direct dissection of human tumor parenchyma from murine tumor …