Carnitine Deficiency - StatPearls - NCBI Bookshelf
2023年8月7日 — This activity reviews the causes, pathophysiology, and clinical presentation of conditions causing carnitine deficiency. It reviews the evaluation and treatment strategies of carnitine deficiency and highlights the role of the interprofessional team in evaluating and treating patients with this condition.
Carnitine deficiency - Types of Metabolic Myopathies (MM)
Carnitine deficiency is one of a group of metabolic muscle diseases that interferes with the processing of food (in this case, fats) for energy production. What are the symptoms of carnitine deficiency? If confined to muscles, this disease causes weakness in the hips, shoulders, and upper arms and legs. The neck and jaw muscles also may be weak.
Role of carnitine in disease - Nutrition & Metabolism
2010年4月16日 — Carnitine is a conditionally essential nutrient that plays a vital role in energy production and fatty acid metabolism. Vegetarians possess a greater bioavailability than meat eaters. Distinct deficiencies arise either from genetic mutation of carnitine transporters or in association with other disorders such as liver or kidney disease.
Systemic Primary Carnitine Deficiency - GeneReviews® - NCBI Bookshelf
2012年3月15日 — Systemic primary carnitine deficiency (CDSP) is a disorder of the carnitine cycle that results in defective fatty acid oxidation. It encompasses a broad clinical spectrum including the following:
Carnitine - Health Professional Fact Sheet - Office of Dietary ...
Introduction. Carnitine, derived from an amino acid, is the generic term for several compounds, including L-carnitine, acetyl-L-carnitine, and propionyl-L-carnitine [1]. Carnitine is naturally present in many foods—especially foods of animal origin—and is available as a dietary supplement.
Carnitine Deficiency - Cedars-Sinai
Carnitine deficiency is when not enough (less than 10%) of the nutrient carnitine is available to cells in the body. This can cause muscle weakness and heart or liver problems. You get carnitine through some of the foods you eat. It plays an important role in …
The Role of l-Carnitine in Mitochondria, Prevention of Metabolic ...
l-carnitine has been used as a therapeutic agent in many conditions associated with metabolic disorders and carnitine deficiency [87,88]. A deficiency of l-carnitine can lead to impaired mitochondrial function and cellular metabolic alterations that may underlie many disease states.
l-carnitine: Nutrition, pathology, and health benefits - PMC
Secondary carnitine deficiency (SCD) is triggered by excessive carnitine loss, a couple of metabolic disorders, poor carnitine content in the diet or malabsorption, Fanconi syndrome (free carnitine loss through renal tubule), peritoneal dialysis or elevated excretion of acyl-carnitine (Winter SC, 2003). As a minimum, 15 syndromes have been ...
Role of carnitine and its derivatives in the development and …
2018年3月7日 — Since L-carnitine (LC) has an indispensable role in lipid metabolism via its involvement in the β-oxidation of long-chain fatty acids and it has antioxidant properties as well, carnitine...
DISORDERS OF CARNITINE TRANSPORT AND THE CARNITINE CYCLE
Carnitine plays an essential role in the transfer of long-chain fatty acids across the inner mitochondrial membrane. This transfer requires enzymes and transporters that accumulate carnitine within the cell (OCTN2 carnitine transporter), conjugate ...