CDK1 Gene - GeneCards | CDK1 Protein | CDK1 Antibody
2024年10月1日 · CDK1 (Cyclin Dependent Kinase 1) is a Protein Coding gene. Diseases associated with CDK1 include Polyploidy and Retinoblastoma. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Loss of proteins required for interphase microtubule organization from the centrosome.
Targeting CDK1 in cancer: mechanisms and implications
2023年6月13日 · Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as promising candidate targets for cancer treatment. These proteins complexed with cyclins play a critical role...
The Cyclin-dependent kinase 1: more than a cell cycle regulator
2023年10月28日 · CDK1, the first identified member of the Cdk family, is conserved in all organisms and regulates the transition between the G2 phase and mitosis. The activity of CDK1 is modulated by its...
CDK1 structures reveal conserved and unique features of the …
2015年4月13日 · CDK1 is the only essential cell cycle CDK in human cells and is required for successful completion of M-phase. It is the founding member of the CDK family and is conserved across all...
An overview of Cdk1-controlled targets and processes
2010年5月13日 · In this review we discuss currently known targets of Cdk1 in the budding yeast S. cerevisiae and highlight the role of Cdk1 in several crucial processes including maintenance of genome stability.
CDK1 cyclin dependent kinase 1 [ (human)] - National Center for ...
2024年11月3日 · cyclin-dependent kinase 1 (Cdk1), a known target of E2F1, is involved in G1 checkpoint regulation, as Cdk1 knockdown hindered G1/S progression, while Cdk1 overexpression rescued RCC1 knockdown-mediated effect on G1 cell cycle progression.
Quantitative differences between cyclin-dependent kinases …
2021年10月12日 · These mouse studies challenged the indispensable roles of different CDKs during the cell cycle and revealed possible compensation between members of the CDK family. Given that CDK1 is the only essential cell-cycle CDK in mice, why metazoans contain multiple cell-cycle CDKs is a long-standing puzzle.
The Cyclin-dependent kinase 1: more than a cell cycle regulator
2023年11月11日 · CDK1, the first identified member of the Cdk family, is conserved in all organisms and regulates the transition between the G2 phase and mitosis. The activity of CDK1 is modulated by its binding to cyclin B1 and by its phosphorylation on crucial residues.
Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and ...
2012年3月3日 · Cyclin-dependent kinase 1 (Cdk1) is an archetypical kinase and a central regulator that drives cells through G2 phase and mitosis. Knockouts of Cdk2, Cdk3, Cdk4, or Cdk6 have resulted in viable mice, but the in vivo functions of Cdk1 have not …
CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and …
2016年9月16日 · CDK1 is one of the most pleiotropic cell cycle regulators; it not only primarily interacts with cyclin B to drive the G 2 -M transition but also binds to other interphase cyclins (cyclin D1, E,...
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