A cross-chiral RNA polymerase ribozyme - Nature
2014年10月29日 — The ribozyme is thought to interact with its substrates via tertiary contacts rather than Watson–Crick base pairing. This unexpected finding will add a new dimension to …
Prebiotic chiral transfer from self-aminoacylating ribozymes
2024年9月12日 — Using a model system of self-aminoacylating D-ribozymes and epimerizable activated amino acid analogs, we test the chiral selectivity of 15 ribozymes derived from an …
Mirror-image T7 transcription of chirally inverted ribosomal and ...
2022年10月27日 — Here, we chemically synthesized a 100-kilodalton mirror-image T7 RNA polymerase, which enabled efficient and faithful transcription of the full-length mirror-image 5 …
Ribozyme crosses chirality borders - Nature
2015年1月7日 — Now, Sczepanski and Joyce show that polymerization of both D - and L -RNA may have emerged together, thanks to ribozymes capable of cross-chiral RNA polymerization. …
The model structure of the hammerhead ribozyme formed by …
2021年1月1日 — The model of mixed chirality between L-hammerhead ribozyme with D-RNA substrate is based on nucleotide sequence complementarity. Two short heterochiral helixes …
Cross-chiral exponential amplification of an RNA enzyme
2024年10月22日 — An RNA ligase ribozyme that catalyzes the joining of RNA molecules of the opposite chiral handedness was optimized for the ability to synthesize its own enantiomer from …
Cross-chiral-Ribozyme-Hold-Clues - Chemical & Engineering News
2014年11月4日 — Researchers have developed the first cross-chiral biocatalyst—a right-handed (D) RNA enzyme that catalyzes the linkage of left-handed (L) RNA nucleotides into L-RNA …
Prebiotic chiral transfer from self-aminoacylating ribozymes may …
2024年9月24日 — Using a model system of self-aminoacylating D-ribozymes and epimerizable activated amino acid analogs, we test the chiral selectivity of 15 ribozymes derived from an …
A Cross-chiral RNA Polymerase Ribozyme - PMC - National …
2014年11月11日 — Cross-chiral assembly of long RNAs a, Assembly of 50mer and 49mer D-RNAs on complementary D-RNA templates through multiple ligation and polymerization events, …
Chirality - SpringerLink
2023年1月1日 — The term chirality, from the Greek word cheir for “hand,” refers to the property of “handedness” possessed by some molecules and macroscopic objects. A molecule or object …