T-cell receptor gene rearrangement - Immunobiology - NCBI …
The germline organization of the human T-cell receptor α and β loci. The arrangement of the gene segments resembles that at the immunoglobulin loci, with separate variable (V), diversity (D), …
Germline TCR contributions - Nature Immunology
2016年9月20日 · Highly diverse repertoires of T cell antigen receptors (TCRs) arise from somatic combinatorial rearrangement of variable-diversity-joining gene segments encoding TCR …
T cell receptor beta germline variability is revealed by inference …
2022年1月7日 · We reveal a rich picture of germline variability and demonstrate how a single nucleotide polymorphism dramatically affects the composition of the whole repertoire. Our …
Germline T cell receptor exchange results in physiological T cell ...
2023年2月1日 · Authors here present an alternative approach to target an exogenous TCR into the physiological Trac locus in the germline of mice, which uncovers that the natural genomic …
Germline-like TCR-α chains shared between autoreactive T
2024年6月13日 · We identify paired αβ (TRA/TRB) T cell receptors (TCRs) in IAR T cells from the blood of healthy, at-risk, new-onset, and established T1D donors, and measured sequence …
Adaptive immune receptor germline gene variation - ScienceDirect
2024年4月1日 · Recognition of antigens by T cell receptors (TCRs) and B cell receptors (BCRs) is a key step in lymphocyte activation. T and B cells mediate adaptive immune responses, which …
A template for multitudes: Germline immune polymorphism of …
2022年12月14日 · Short-read next-generation sequencing has failed to adequately genotype the T cell receptor (TCR) loci, limiting our ability to characterize the role of germline TCR variation. …
T-cell receptors: germline polymorphism and patterns of …
The genomic organization of the T-cell receptor (TCR) gene complexes accounts for many central aspects of T-cell immunobiology, including specificity and diversity. Recent data indicate that …
Germline transcription of multiple TCR-Vbeta genes in cloned T …
Germline transcription of TCR-Vbeta genes was analysed using the reverse transcriptase (RT)-PCR in a clonal T-cell precursor line C1-V13D, a clonal pre-B cell line RAW112 and a mature …
Archaic humans have contributed to large-scale variation in …
This collection of expressed alleles from a diverse population enabled the assembly of a human TCR V, D, and J germline gene database from the four loci, identifying alleles that varied in …