Interleukin 10 - Wikipedia
IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and …
Interleukin 10 - an overview | ScienceDirect Topics
Interleukin 10 (IL-10) is an anti-inflammatory cytokine that is a member of the class-2 cytokines. In humans, interleukin 10 is encoded by the IL10 gene (loc: 1q32.1) and is produced primarily by monocytes and, to a lesser extent, lymphocytes.
Role of Interleukin 10 Transcriptional Regulation in Inflammation …
Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that plays a central role in limiting host immune response to pathogens, thereby preventing damage to the host and maintaining normal tissue homeostasis.
Biology and therapeutic potential of interleukin-10 - PMC
Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide.
Interleukin - StatPearls - NCBI Bookshelf - National Center for ...
2022年8月22日 · Interleukin-9 (IL-9) Th9, Th2, Th17, mast cells, NKT cells, and regulatory T cells produce this cytokine. It enhances T-cell survival, mast cell activation and synergy with erythropoietin. Interleukin-10 (IL-10) Th2 cells produce IL-10. Its principal targets are Th1 cells. It causes inhibition of IL-2 and interferon gamma.
Interleukin-10: new perspectives on an old cytokine - PMC
Interleukin-10 (IL-10) has long been recognized to have potent and broad-spectrum anti-inflammatory activity, which has been unequivocally established in various models of infection, inflammation, and even in cancer. However, because of the marginal successes of the initial clinical trials using recombinant IL-10, some of the interest in this ...
The regulation of IL-10 production by immune cells - Nature
2010年2月15日 · Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage to the host.
Frontiers | The multifaceted nature of IL-10: regulation, role in ...
2023年5月24日 · Circulating interleukin 10 (IL-10) binds as a homodimer to tetrameric IL-10 receptor (IL-10R) complex and induce the downstream activation of Janus kinase 1 (Jak1) and tyrosine kinase 2 (Tyk2) and the subsequent phosphorylation of signal transducer and activator of transcription 3 (STAT3).
Interleukin-10: biology, role in inflammation and autoimmunity
Interleukin-10 is an important molecule with a central role in maintaining health and in the pathogenesis of disease. Known pharmacologic agents and some under investigation can modify IL-10 production in vivo.
IL-10: The Master Regulator of Immunity to Infection
2008年5月1日 · Transgenic mice expressing human interleukin-10 in the antigen-presenting cell compartment show increased susceptibility to infection with Mycobacterium avium associated with decreased macrophage effector function and apoptosis.