Spironolactone Online
Aldosterone is a hormone that regulates salt and water balance in the body. By blocking the action of aldosterone‚ Spironolactone helps to decrease sodium and water retention‚ resulting in a reduction of blood pressure and swelling. Spironolactone is commonly prescribed to treat conditions such as:
Spironolactone - StatPearls - NCBI Bookshelf
2023年7月4日 · Describe the mechanism of action and administration of spironolactone. Outline the adverse effects and contraindications of spironolactone. Summarize the appropriate monitoring and toxicity of spironolactone.
Spironolactone - Wikipedia
Spironolactone, sold under the brand name Aldactone among others, is a diuretic medication primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. [4]
Spironolactone: Uses, Interactions, Mechanism of Action
Mechanism of action Aldosterone is a key hormone in the renin-angiotensin-aldosterone system. By binding to the mineralocorticoid receptor at the distal tubules and collecting duct, it causes sodium reabsorption and potassium secretion, increases vascular stiffness and remodelling, and activates pro-inflammatory pathways. 6 , 11
Pharmacodynamics of spironolactone - Wikipedia
The pharmacodynamics of spironolactone, an antimineralocorticoid and antiandrogen medication, concern its mechanisms of action, including its biological targets and activities, as well as its physiological effects.
ALDACTONE® Clinical Pharmacology - Pfizer Medical Information
12.1 Mechanism of Action. Spironolactone and its active metabolites are specific pharmacologic antagonists of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule.
Spironolactone: Dosage, Mechanism/Onset of Action, Half-Life
2020年2月17日 · Includes Spironolactone indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more.
Spironolactone | Description, Mechanism of Action, Uses, & Side …
2024年11月1日 · Spironolactone exerts its effects by binding to and blocking receptors for the hormone aldosterone, which is secreted by the adrenal glands and functions to regulate sodium and water retention and potassium excretion.
Spironolactone - an overview | ScienceDirect Topics
The mechanism by which spironolactone is believed to work is by decreasing sebum production and inhibiting type 2 17β-hydroxysteroid dehydrogenase, thereby inhibiting the conversion of androstenedione to testosterone [57,58].
Spironolactone - SpringerLink
2022年10月27日 · Spironolactone is a potassium-sparing diuretic with antiandrogenic effects since it decreases Testosterone levels, competitively blocks the cytosolic androgen receptor, reduces DHT effects in target tissues, and inhibits the mineralocorticoid receptor.
Spironolactone: An Old Friend Rediscovered - PMC - National …
2007年1月31日 · Spironolactone was the first diuretic engineered expressly to block a particular renal transport process: to decrease Na + reabsorption within the collecting duct, a primary locus of aldosterone action within the kidney.
Spironolactone - Uses, Side Effects, and More - WebMD
2024年7月21日 · How does spironolactone work (mechanism of action)? Spironolactone works by blocking a hormone called aldosterone in your body. Aldosterone causes your body to retain sodium and water, which can...
SPIRONOLACTONE tablet, coated - DailyMed
2023年2月16日 · 12.1 Mechanism of Action - Spironolactone and its active metabolites are specific pharmacologic antagonists of aldosterone, acting primarily through competitive binding of receptors at the ...
Spironolactone | C24H32O4S | CID 5833 - PubChem
Spironolactone is a potassium -sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.
spironolactone (Rx) - Medscape Drugs & Diseases
Based on mechanism of action and findings in animal studies, spironolactone may affect sex differentiation of the male during embryogenesis; rat embryofetal studies report feminization of...
SPIRONOLACTONE- spironolactone tablet, film coated - DailyMed
2024年8月12日 · 12.1 Mechanism of Action. Spironolactone and its active metabolites are specific pharmacologic antagonists of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in …
Spironolactone - PubMed
2023年7月4日 · Spironolactone is a medication used in the management and treatment of hypertension and heart failure with some indications aside from cardiovascular disease. It is in the mineralocorticoid receptor antagonist class of drugs.
Spironolactone | Treatment & Management | Point of Care
2023年7月4日 · Mechanism of Action. Spironolactone belongs to the drug class of mineralocorticoid receptor antagonists, and it is a nonselective antagonist that can bind to androgen and progesterone receptors.
Mechanistic Effects of Spironolactone on Cardiovascular and Renal ...
2020年1月20日 · We assessed effects of 12 months of treatment with spironolactone on biomarkers reflecting myocardial stress, myocardial injury, renal function, and systemic inflammation.
Spironolactone (oral route) - Mayo Clinic
Spironolactone is a potassium-sparing diuretic (water pill). It prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. This medicine is also used to treat or prevent hypokalemia (low potassium levels in the blood).