Heteroplasmy - Wikipedia
Heteroplasmy is the presence of more than one type of organellar genome (mitochondrial DNA or plastid DNA) within a cell or individual. It is an important factor in considering the severity of mitochondrial diseases.
Heteroplasmy - an overview | ScienceDirect Topics
Heteroplasmy is defined as a state in which more than one chloroplast or mitochondrial genotype occurs in an organism, a state that is widely found in land plants, algae, fungi, and animals (Gillham, 1994).
Heteroplasmy - an overview | ScienceDirect Topics
Heteroplasmy is a condition where two or more different variants of mtDNA coexist within a cell. This can refer either to the presence of two normal variants, i.e. different healthy mtDNA haplotypes, or to the presence of healthy and mutated mtDNA in the same cell.
The dynamics of mitochondrial DNA heteroplasmy: implications
2015年8月18日 · The level of heteroplasmy can vary between cells in the same tissue or organ, from organ to organ within the same person, and between individuals in the same family.
Heteroplasmy and Individual Mitogene Pools: Characteristics and ...
Technically, heteroplasmy refers to the presence of more than one type of mitochondrial DNA (mtDNA) in an individual . Heteroplasmy is a copy-level mitogenome variation, and each cell, tissue, organ, and individual can be a reservoir of various variants .
Mitochondrial DNA heteroplasmy in human health and disease
Mitochondrial heteroplasmy may be defined as a dynamically determined co-expression of wild-type (WT)-inherited polymorphisms and somatic mutations in varying ratios within individual mtDNA genomes distributed throughout the intraorganelle compartments of individual cells.
What is a Heteroplasmy and Why Do I Care? - DNAeXplained
2021年6月10日 · Heteroplasmy Bottom Line. You can suspect a heteroplasmy if you have full sequence matches, but no exact matches. If you have a heteroplasmy in the HVR1 region, understand that you may not have many or any matches in the HVR1 and HVR2 regions. The remedy is to test at the full sequence level and check matches there.
Deleterious heteroplasmic mitochondrial mutations are associated …
2023年9月30日 · Unlike the nuclear genome, mitochondrial DNA (mtDNA) can be present at 1000 s to 10,000 s copies in somatic cells and variants may exist in a state of heteroplasmy, where only a fraction of the...
Heteroplasmy as a common state of mitochondrial genetic
2006年6月9日 · Heteroplasmy is defined as a state in which more than one mitochondrial genotype occurs in an organism. The ratio of different types of mtDNAs in a heteroplasmic population may be variable, but usually one mitotype is prevalent, while the alternative one(s) are present in a very low proportion.
Heteroplasmy in action: tracking mtDNA segregation dynamics
2024年9月10日 · Heteroplasmy arises when a single cell contains distinct mtDNA genotypes. The degree of heteroplasmy varies depending on the rates of mutation accumulation across the lifetime of an organism, and this can have important consequences on mitochondrial function (Wallace and Chalkia, 2013 ).