Structural Characterization Study of a Lipid Nanocapsule …
网页2022年2月28日 · Lipid nanocapsules (LNCs) are solvent-free drug nanocarriers permitting entrapment of paclitaxel and increasing its antitumoral effect in animal models after i.v. injection. The tolerance and efficacy of LNCs after repeated dose i.v. administration were assessed in mice.
Frontiers | Lipid-based oral formulation in capsules to improve …
网页2023年8月23日 · Lipid-based formulations in capsules are commonly used to improve the delivery of poorly water-soluble drugs. These formulations, also known as lipid-based drug delivery systems (LBDDS), use lipids as carriers to enhance the solubility, absorption, and bioavailability of such drugs.
Lipid shell lipid nanocapsules as smart generation lipid nanocarriers ...
网页2021年10月1日 · Lipid nanocapsules (LNCs) are lipid-based nanocarriers that have found application as drug delivery systems, in diagnostics, and theranostics. They are biocompatible and able to circumvent biological membranes easily because of their morphological features and structural facets.
Oral lipid-based drug delivery systems – an overview
网页2013年12月1日 · As many drugs are successfully marketed as lipid-based formulations, the lipid-based drug delivery system (LBDDS) has a wide scope in terms of solubility and bioavailability enhancement. This review focused on the current trends in the field of LBDDS with respect to formulation approaches and their characterization.
Current approaches in lipid-based nanocarriers for oral drug …
网页2021年2月2日 · Lipid nanocapsules are vesicular nanocarriers constituted by an oily phase and an aqueous phase, stabilised by surfactants and a polymeric shell. Many physicochemical properties, and therefore the biological identity, of nanocarriers depend on their surface characteristics.
Full article: Review and analysis of FDA approved drugs using lipid ...
网页2017年7月6日 · Lipid-based drug delivery systems (LBDDS) are one of the most studied bioavailability enhancement technologies and are utilized in a number of U.S. Food and Drug Administration (FDA) approved drugs.
Lipid nanocapsules: A new platform for nanomedicine
网页2009年9月11日 · Lipid nanocapsules provide a new tool which contributes to nanomedicine development. Using FDA-approved constituents, LNCs are prepared by a solvent-free process to obtain particles of less than 100 nm with monodispersity. These LNCs provide considerable drug encapsulation capacity and also exhibit sustained-release functions at the site of action.
Hybrid Lipid Nanocapsules: A Robust Platform for mRNA Delivery
网页In this study, we present a robust and biodegradable mRNA delivery nanoplatform based on engineered hybrid lipid nanocapsules (hLNCs), a hybrid structure of lipids and polymer. hLNCs present a compelling strategy in nucleic acid delivery systems by leveraging the advantages of both lipids and polymer nanoparticles.
Lipid Nanocapsule: A Novel Approach to Drug Delivery System
网页The PEG (polyethyleneglycol) is primarily utilised to produce nanocapsules and is a critical parameter influencing capsule residence time. With their broad drug-loading features, lipid nanocapsules have a distinct advantage in drug delivery systems, such as the capacity to encapsulate hydrophilic or lipophilic pharmaceuticals.
Lipid nanoparticles for mRNA delivery | Nature Reviews Materials
网页2021年8月10日 · This Review discusses lipid nanoparticle design for mRNA delivery, highlighting key points for clinical translation and preclinical studies of lipid nanoparticle–mRNA therapeutics for various...