Lysostaphin - Wikipedia
Lysostaphin is a 27 KDa glycylglycine endopeptidase, an antibacterial enzyme which is capable of cleaving the crosslinking pentaglycine bridges found in the cell wall peptidoglycan of certain staphylococci. Lysostaphin was first isolated from a culture of Staphylococcus simulans by Schindler and Schuhardt in 1964. [2]
Lysostaphin: A Staphylococcal Bacteriolysin with Potential Clinical ...
Lysostaphin is the only class III staphylococcin described so far. It exhibits a high degree of antistaphylococcal bacteriolytic activity, being inactive against bacteria of all other genera.
溶葡萄球菌酶 - 百度百科
溶葡萄球菌酶(Lysostaphin)是一种含Zn 2+ 的金属蛋白酶，具有内切肽酶活性，能特异性水解细菌细胞壁肽聚糖五甘氨酸肽键桥（第2与第3位Gly形成的肽键），从而快速溶解细菌细胞壁而产生破壁溶菌作用 [1] 。溶葡萄球菌酶的理化性质、抗菌作用机制以及体内外药效 ...
Two-site recognition of Staphylococcus aureus peptidoglycan by ... - Nature
2019年11月4日 · Lysostaphin is a bacteriolytic enzyme targeting peptidoglycan, the essential component of the bacterial cell envelope. It displays a very potent and specific activity toward staphylococci,...
Lysostaphin: Engineering and Potentiation toward Better …
2022年9月9日 · Lysostaphin is a potent bacteriolytic enzyme with endopeptidase activity against the common pathogen Staphylococcus aureus. By digesting the pentaglycine crossbridge in the cell wall peptidoglycan of S. aureus including the methicillin-resistant strains, lysostaphin initiates rapid lysis of planktonic and sessile cells (biofilms) and has great ...
Therapeutic applications of lysostaphin against Staphylococcus …
2020年12月31日 · Lysostaphin can exert major therapeutic benefits over antibiotics: (i) Lysostaphin is highly active with MIC value ranges between 0·001 and 0·064 μg ml −1. (ii) Lysostaphin is active against drug-resistant S. aureus .
Therapeutic applications of lysostaphin against Staphylococcus aureus ...
Lysostaphin is a 27 kDa zinc metallo antimicrobial lytic enzyme that is produced by Staphylococcus simulans biovar staphylolyticus and was first discovered in the 1960s. Lysostaphin is highly active against S. aureus strains irrespective of their drug-resistant patterns with a minimum inhibitory concentration of ranges between 0·001 and 0·064 ...
Lysostaphin: an antistaphylococcal agent - Applied Microbiology …
2008年7月8日 · This review article presents a current understanding of the lysostaphin and its applications in therapeutic agent as a treatment against antibiotic-resistant S. aureus and methicillin-resistant S. aureus (MRSA) infections, either alone or in …
Lysostaphin - an overview | ScienceDirect Topics
Lysostaphin is a bacteriocin, encoded by Staphylococcus simulans with antibacterial activity against S. aureus, harboring an N-terminal glycyl-glycine M23 endopeptidase domain (EAD) and a C-terminal SH3b domain (CBD).
Lysostaphin | C74H112Cl2N6O11 | CID 167312533 - PubChem
Lysostaphin | C74H112Cl2N6O11 | CID 167312533 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
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