RUNX2 - Wikipedia
Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the RUNX2 gene. RUNX2 is a key transcription factor associated with osteoblast differentiation.
RUNX2 gene - MedlinePlus
The RUNX2 gene provides instructions for making a protein that is involved in the development and maintenance of the teeth, bones, and cartilage. Learn about this gene and related health conditions.
Whole Aspect of Runx2 Functions in Skeletal Development
2022年5月21日 · Runx2 is a good target for the treatment of osteoporosis by increasing bone formation. As Runx2 has multiple functions in osteoblasts and chondrocytes, however, it is important to specifically upregulate Runx2 expression or activity in osteoblast lineage cells.
RUNX2 Gene - GeneCards | RUNX2 Protein | RUNX2 Antibody
2024年10月2日 · RUNX2 (RUNX Family Transcription Factor 2) is a Protein Coding gene. Diseases associated with RUNX2 include Cleidocranial Dysplasia 1 and Metaphyseal Dysplasia With Maxillary Hypoplasia With Or Without Brachydactyly. Among its related pathways are Gene expression (Transcription) and RUNX2 regulates bone development.
RUNX2 RUNX family transcription factor 2 [ (human)]
2024年11月2日 · Runx2 is a novel and important downstream mediator of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway that is linked to metastatic properties of breast cancer cells. Runx2 protein levels are cell cycle-regulated with respect to the G(1)/S phase transition in U2OS, HOS, G292, and 143B cells.
Transcriptional Programming in Arteriosclerotic Disease: A …
The human RUNX2 gene is located at the short arm of chromosome 6 at position 21.1 (6p21.1) 27; and the murine Runx2 gene is located on chromosome 17 28. Expression runx2 is transcriptionally regulated by two promoters, the distal P1 promoter and the proximal P2 promoter .
Runx2: Structure, function, and phosphorylation in osteoblast ...
Runx2 is a master transcription factor for osteogenesis. The most important phenomenon that makes this protein a master regulator for osteogenesis is its structural integrity. In response to various stimuli, the domains in Runx2 interact with several proteins and regulate a number of cellular events ….
A RUNX2 stabilization pathway mediates physiologic and ... - Nature
2020年5月8日 · Nature Communications - Runx2 is essential for tuning the generation of bone from skeletal stem cells (SSCs). Here, the authors demonstrate that the CK2/HAUSP pathway stabilizes RUNX2 protein...
Runx2: A master organizer of gene transcription in developing …
2005年9月26日 · Runx2 binds a specific DNA sequence to regulate gene transcription and is localized to discrete subcellular foci by the nuclear matrix. Runx2 interacts with CBFβ, as well as other proteins that are classified as corepressors, coactivators, or transcription factors.
Runx2 is required for the proliferation of osteoblast ... - Nature
2018年9月10日 · Runx2 directly regulated Fgfr2 and Fgfr3, increased the proliferation of osteoblast progenitors, and augmented the FGF2-induced proliferation.