Rapid Quantification of Pharmaceuticals via 1H Solid-State NMR ...
2022年11月23日 · For glycine, CRAMPS spectra recorded at 35 to 55 kHz all provided higher resolution than fast MAS experiments at 65 kHz. Besides challenges with data acquisition, 1 H SSNMR data analysis can also be difficult.
13C solid-state NMR analysis of the most common pharmaceutical ...
2016年4月15日 · Therefore, in the 13 C ssNMR spectra of their samples broad and overlapping signals are usually observed. In this work the most common pharmaceutical excipients used in the solid drug formulations have been analyzed.
High-Resolution Solid-State 2H NMR Spectroscopy of Polymorphs of Glycine
2011年9月22日 · High-resolution solid-state 2H MAS NMR studies of the α and γ polymorphs of fully deuterated glycine (glycine-d5) are reported. Analysis of spinning sideband patterns is used to determine the 2H qu...
Solid-state nuclear magnetic resonance - Wikipedia
Solid-state NMR (ssNMR) spectroscopy is a technique for characterizing atomic level structure in solid materials e.g. powders, single crystals and amorphous samples and tissues using nuclear magnetic resonance (NMR) spectroscopy.
Comment to 13C-NMR studies of α and γ polymorphs of glycine
1998年6月1日 · According to literature data the 13 C-NMR spectrum of glycine, recorded under magic angle spinning and cross polarization (13 C CP/MAS), is observed as clearly cut single line corresponding to C(O)O − signal (δ iso =176.20 ppm) and broaden signal from CH 2 carbon (δ iso =43.5 ppm) [3]. Such result is also consistent with our previous ...
A Combined Near-Infrared and Mid-Infrared Spectroscopic …
2022年6月15日 · For the normalized, second derivative ATR spectra, the important spectral information can be observed at 906, 1036, 1111, 1330, and 1414 cm −1. These specific features of glycine are attributed to the presence of CH 2 rocking, C-N stretching, NH 3 rocking, CH 2 wagging, and O-C=O symmetric stretching in the spectra, respectively .
Ultra-wideline 14N solid-state NMR as a method for differentiating ...
2015年1月29日 · Nitrogen-14 solid-state NMR (SSNMR) is utilized to differentiate three polymorphic forms and a hydrochloride (HCl) salt of the amino acid glycine. Frequency-swept Wideband, Uniform Rate, Smooth Truncated (WURST) pulses were used in conjunction with Carr-Purcell Meiboom-Gill refocusing, in the form of the WUR Polymorphism
Monitoring the influence of additives on the crystallization …
2022年12月1日 · In this contribution, using DNP solid-state NMR (ssNMR) experiments, we investigated the influence of different additives such as methanol (MeOH) or sodium chloride (NaCl), on the crystallization process of glycine in water.
1H and 13C NMR studies of glycine in anisotropic media: double …
The (1)H NMR spectrum of glycine in stretched gelatin gel and in cromolyn liquid crystal displays a well-resolved doublet due to (1)H-(1)H dipolar interaction. Multiple spectra were obtained within a wide range of offset frequencies of partially saturating …
Room-temperature dynamic nuclear polarization enhanced NMR spectroscopy ...
2021年11月25日 · The ODNP-enhanced 13 C NMR spectra of U– 13 C serine (a), alanine (b), glycine (c), proline (d), and glucose (e) are scaled with the number of scans for visualizing directly the enhancement...