Krebs Cycle Reimagined: The Emerging Roles of Succinate ... - Cell …
网页2018年8月9日 · Succinate and itaconate have therefore emerged in several areas of cell function, playing key, but opposing, signaling roles that link mitochondrial function to the rest of the cell. Here, we discuss these recent studies and present novel therapeutic options for the injury that occurs in IR and in inflammatory diseases.
Why succinate? Physiological regulation by a mitochondrial
网页2022年4月28日 · Succinate, by equilibrating with the CoQ pool, enables the status of this central bioenergetic parameter to be communicated from mitochondria to the rest of the cell, into the circulation and...
Succinate metabolism: a promising therapeutic target for …
网页2023年9月22日 · Succinate serves as an essential circulating metabolite within the tricarboxylic acid (TCA) cycle and functions as a substrate for succinate dehydrogenase (SDH), thereby contributing to energy production in …
Rethinking succinate: an unexpected hormone-like metabolite in …
网页2021年9月1日 · Succinate is a pleiotropic signaling metabolite produced by both host and microbiota that acts akin to hormones and cytokines by engaging succinate receptor 1 (SUCNR1). As an integrative hub of inflammatory response in macrophages, perturbations of the succinate–SUCNR1 axis might cause dysfunction of key metabolic tissues.
Succinate: a metabolic signal in inflammation - PubMed
网页Succinate is an intermediate of the tricarboxylic acid (TCA) cycle, and plays a crucial role in adenosine triphosphate (ATP) generation in mitochondria. Recently, new roles for succinate outside metabolism have emerged. Succinate stabilizes the transcription factor hypoxia-inducible factor-1α (HIF-1 ….
The Role of Succinate in the Regulation of Intestinal Inflammation
网页2018年12月22日 · Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well as …
Succinate Dehydrogenase Supports Metabolic Repurposing of ... - Cell …
网页To examine how succinate within macrophages might have opposing effects on pro- and anti-inflammatory pathways, we investigated two of the ways in which succinate could act within the cell, either by enhancing HIF-1α activation by inhibiting prolyl hydroxylase (PHD) function or as a result of oxidation by mitochondrial succinate dehydrogenase ...
Succinate: a metabolic signal in inflammation - Cell Press
网页2013年12月19日 · Succinate can signal through succinate receptor 1 (SUCNR1) and act in synergy with Toll-like receptors (TLRs) to boost dendritic cell function. NAD + exerts several anti-inflammatory effects by activating sirtuins, a class of NAD + -dependent deacetylases.
Molecular activation and G protein coupling selectivity of human ...
网页2024年5月14日 · Succinate (SA) is a classic intermediate metabolite of the TCA cycle and is produced in mitochondria under normal physiological conditions. 1 SA accumulates within cells and is secreted into...
Molecular basis of ligand recognition and activation of the human ...
网页2024年6月4日 · Succinic acid, once considered merely a tricarboxylic acid cycle intermediate, 1 has been recognized for its significant role in influencing mitochondrial reactive oxygen species homeostasis. 2...