Tophus in Gout: Tophi Removal, Treatment, and More - Healthline
网页2023年6月27日 · A tophus (plural: tophi) happens when crystals of the compound known as sodium urate monohydrate, or uric acid, builds up around your joints. Tophi often look like swollen, bulbous growths on...
What Are Gout Tophi? Causes, Symptoms, and Treatments
网页2019年5月28日 · Gout flare-ups occur when uric acid forms crystals that settle in a joint, often the big toe, where it causes warmth, redness, and excruciating pain. One highly visible manifestation is gout tophi, or large bumps that form where gout crystals have accumulated. Gout can also affect other joints, such as the knees, ankles, wrists, and elbows.
Gout Tophi Causes, Treatment, and Removal - Verywell Health
网页2024年9月19日 · Tophi are deposits of uric acid crystals that accumulate in joints due to hyperuricemia, a condition in which there are high levels of uric acid in the blood. Tophi are most commonly associated with gout, and appear as lumps under the skin, typically around fingers, toes, and other joints.
Pharmacologic urate-lowering therapy and treatment of tophi ... - UpToDate
网页2024年6月11日 · The prevention of recurrent gout flares, tophi, and progressive structural joint damage generally requires the long-term use of drugs that reduce the serum urate concentration either by enhancing renal excretion of uric acid (uricosuric agents) or by decreasing urate synthesis (xanthine oxidase inhibitors [XOIs]), a …
Gout Symptoms and Diagnosis - Johns Hopkins Arthritis Center
网页Frequently, uric acid tophi (hard, uric acid deposits under the skin) are present and contribute to bone and cartilage destruction. Tophi are diagnostic for chronic tophaceous gout. Tophi can be found around joints, in the olecranon bursa, or at the pinna of the ear.
Interventions for tophi in gout - PMC - National Center for ...
网页2021年8月11日 · Tophi are nodules that develop in people with uncontrolled chronic gout. Tophi can become infected, cause pain and lead to reduced function. Tophi can be treated with urate‐lowering drugs (e.g. benzbromarone, probenecid, allopurinol, febuxostat, pegloticase, lesinurad), surgical removal or other interventions. Study characteristics
Tophaceous gout: Symptoms, treatment, and more - Medical News Today
网页2021年3月31日 · It causes uric acid masses called tophi to form under the skin over joints and tissues. People can usually treat tophaceous gout by using uric acid-lowering medications and changing certain...
2020 American College of Rheumatology Guideline for the Management of Gout
网页2023年10月10日 · Initiating ULT is strongly recommended for gout patients with any of the following: ≥1 subcutaneous tophi; evidence of radiographic damage (any modality) attributable to gout; OR frequent gout flares, with frequent being defined as ≥2 annually.
Gout - Symptoms and causes - Mayo Clinic
网页2022年11月16日 · Untreated gout may cause deposits of urate crystals to form under the skin in nodules called tophi (TOE-fie). Tophi can develop in several areas, such as your fingers, hands, feet, elbows or Achilles tendons along the backs of your ankles.
Interventions for Tophi in Gout: A Cochrane Systematic …
网页2014年9月1日 · An open-label extension trial noted that longterm maintenance of serum uric acid < 6.0 mg/dl with febuxostat led to a reduction in tophi. The case series and reports looked at surgical, pharmacological, and other interventions, as well as combination therapies. All surgical interventions reported improvement in pain and/or function.