Myostatin - Wikipedia
Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. [6] Myostatin is a myokine that is produced and released by myocytes and acts on muscle cells to inhibit muscle growth. [7]
Slowing or reversing muscle loss - Mayo Clinic
2014年4月10日 · The discovery that the growth and differentiation factor-8 (GDF-8), also known as myostatin, functions as a potent negative regulator of muscle growth has led to the exploration of whether it can serve as a mediator of sarcopenia or cachexia and as a therapeutic target.
What Does Myostatin Inhibition Do? + Risks & Side Effects
2022年12月15日 · Myostatin is a human growth factor that prevents excessive muscle growth, and abnormally high levels can cause the loss of muscle mass. Despite the lack of proper data, myostatin has become a hot topic among athletes and bodybuilders, who claim that inhibiting it can boost muscle growth.
Myostatin and its Regulation: A Comprehensive Review of Myostatin …
2022年6月22日 · Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle (SM), and its crucial involvement in several disorders has …
Myostatin: Basic biology to clinical application - PubMed
In this chapter, we review myostatin biology, including intracellular and extracellular regulatory pathways, and the role of myostatin in modulating physiologic processes, such as muscle growth and aging.
Myostatin: A Skeletal Muscle Chalone - PMC - PubMed Central …
Myostatin (GDF-8) was discovered 25 years ago as a new transforming growth factor-β family member that acts as a master regulator of skeletal muscle mass. Myostatin is made by skeletal myofibers, circulates in the blood, and acts back on myofibers to limit growth.
Targeting the myostatin signaling pathway to treat muscle loss …
Myostatin (MSTN; also known as GDF-8) is a secreted signaling molecule that was originally identified in a screen for new members of the TGF-β superfamily (1).
Novel myostatin-specific antibody enhances muscle strength in …
2021年1月25日 · Myostatin, a member of the transforming growth factor-β superfamily, is an attractive target for muscle disease therapy because of its role as a negative regulator of muscle growth and strength....
Myostatin: A Skeletal Muscle Chalone - PubMed
2023年2月10日 · Myostatin (GDF-8) was discovered 25 years ago as a new transforming growth factor-β family member that acts as a master regulator of skeletal muscle mass. Myostatin is made by skeletal myofibers, circulates in the blood, and acts back on myofibers to limit growth.
Myostatin-related muscle hypertrophy - MedlinePlus
Myostatin-related muscle hypertrophy is a rare condition characterized by reduced body fat and increased muscle size. Affected individuals have up to twice the usual amount of muscle mass in their bodies. They also tend to have increased muscle strength.
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