The cornified envelope: a model of cell death in the skin
2005年4月1日 · Keratinocytes move from a proliferative cell type in the basal cell layer of the EPIDERMIS through the granular layer where the CORNIFIED ENVELOPE is formed, to an association of flattened, dead ...
角化套膜与皮肤屏障功能 - 百度学术
角化套膜 (Cornified envelopes,CE)是位于表皮最外层,背衬于角质形成细胞的细胞膜内侧,一种极为强韧且巨大的不溶性构造物.在皮肤屏障功能中起到物理,化学,渗透等重要作用.它由源自棘层细胞的外皮蛋白 (involucria),颗粒层细胞的兜甲蛋白 (loricrin)等为主要构成成分 ...
Cell death by cornification - ScienceDirect
2013年12月1日 · Abstract. Epidermal keratinocytes undergo a unique form of terminal differentiation and programmed cell death known as cornification. Cornification leads to the formation of the outermost skin barrier, i.e. the cornified layer, as well as to …
Epidermal cornification is preceded by the expression of a
2017年12月12日 · Here, we report that cornification is associated with the expression of specific genes that control multiple steps of pyroptosis, another form of cell death that involves the processing and ...
Live imaging of alterations in cellular morphology and organelles ...
2020年3月26日 · Various changes occur in granular cells at the uppermost stratum granulosum during cornification. To understand the temporal details of this process, we visualized the cell shape and organelles of...
Cornification of the Skin: A Non-apoptotic Cell Death Mechanism
2016年11月15日 · Cornification, the keratinocyte differentiation programme (occurring in upper layer), is a slow, coordinated process in space and time that allows the formation of a dead cells (corneocytes) layer to create a physical barrier for the skin.
Structure and functions of keratin proteins in simple, stratified ...
Recently, new functions of keratins and keratin filaments in cell signaling and intracellular vesicle transport have been discovered. It is currently understood that all stratified epithelia are keratinized and that some of these keratinized stratified epithelia cornify by forming a Stratum corneum. The processes of keratinization and ...
The Process of Cornification Evolved From the Initial Keratinization …
2016年1月1日 · During land adaptation of the integument in tetrapods, an efficient stratum corneum was originated through the evolution of numerous corneous proteins in addition to the framework of intermediate filament-keratins present in keratinocytes.
角质层屏障功能中角化包膜重要性的研究 - 百度学术
目的角化包膜 (CE,Cornified Envelope)是角质层细胞的包膜,可为胞间脂质提供正确的结合点.如果CE不能成熟,即使细胞间脂质的数量充足,也不能形成整齐的角质层砖墙状结构.我们的研究旨在开发出一种CE成熟度的评价方法,研究面部及其他部位皮肤的CE成熟度,并探索CE ...
The Process of Cornification Evolved From the Initial Keratinization …
2016年1月1日 · Introduction. The present review aims to summarize comparative aspects of the process of terminal differentiation of keratinocytes in the epidermis and epidermal derivatives of vertebrates indicating the peculiarities present in sauropsids within the general process of vertebrate cornification.